Biosynesi owl logo BIOSYNESI

Software for the human side of medicine.

Two patented platforms. One belief: technology should strengthen human flourishing, not replace it.

2platforms
2patents
20+years of clinical & engineering work

What we build

Tools that meet people where they are — from the operating room to the living room.

U.S. Patent 11,865,327

Platform: Desktop (Windows, Python)

For: neurosurgical teams performing deep-brain stimulation.

NeuroFreq

Frequency signatures of brain tissue, surfaced in real time during DBS surgery.

NeuroFreq aggregates microelectrode recordings across patients to build representative frequency signatures for target brain regions. During surgery, live recordings are matched against those signatures — giving surgeons a continuous read on how close the electrode is to its intended target. Granted U.S. Patent 11,865,327 (January 2024).

Inquire about licensing →

Patent pending

Platform: Web — privacy-first, runs in your browser

For: adults seeking somatic, self-paced support — with clinical and research tiers to follow.

NeuroSpot

A neuroadaptive wellness platform that meets you in the moment.

NeuroSpot is being built as a three-tier platform — beginning with a general-wellness experience anyone can use, and extending into supervised clinical and research applications. The shared principle across tiers: your session is yours. Sensitive data stays on your device.

Join the early-access list →

“Love is the ethical direction of power.”
— Guiding principle of our work. Read the full framework at Trailmaid.

Who we are

Founded by Kevin M. Biddell.

Biosynesi is the software arm of a wider mission. Its founder, Kevin M. Biddell, holds a PhD in biomedical engineering and is a Licensed Independent Social Worker (LISW) in private clinical practice in Ohio. He is also the author of Gwen’s Meadow and the Trauma Healing Coloring Workbook, both published through Hope for a Village.

That combination — engineer, clinician, author, ethicist — is rare, and it shapes everything Biosynesi makes:

  • Software grounded in real clinical practice, not assumed use cases.
  • Engineering that respects the nervous system on the other side of the screen.
  • An explicit ethical framework, published openly at Trailmaid.

Selected publications

Peer-reviewed work behind the products.

  1. Merola, A., Mandybur, G., Biddell, K., Tareen, T. K., Wilson-Perez, H., Espay, A. J., & Duker, A. P. (2017). Subthalamic or red nucleus? A puzzling question arising during intraoperative recording for DBS. Clinical Neurophysiology, 128(4), 558–560.
  2. Biddell, K., Duker, A., & Mandybur, G. (2015). Can microelectrode recording be used to accurately differentiate the red nucleus from subthalamic nucleus? North American Neuromodulation Society, Las Vegas, NV.
  3. Biddell, K., Duker, A., & Mandybur, G. (2015). Hybrid automated computer program for localization of STN borders during DBS surgery. Minnesota Neuromodulation Symposium, Minneapolis, MN.
  4. Biddell, K., & Johnson, J. (2013). The effects of NMDA receptor model time dynamics over the short and long term when set to striatal dorsolateral and ventromedial medium spiny neurons. 6th IEEE EMBS Conference on Neural Engineering, San Diego, CA.
  5. Biddell, K., & Johnson, J. (2013). A biophysical model of cortical glutamate excitation of medium spiny neurons in the dorsal lateral striatum. 56th IEEE Midwest Symposium on Circuits and Systems, Columbus, OH.
  6. Biddell, K., Li, J., & Johnson, J. (2003). A biological mapping of a learned avoidance model to the basal ganglia. Third IEEE Symposium on Bioinformatics and Bioengineering, Washington, DC.

Funded in part by the Mayfield Education and Research Foundation.

Work with us

Let’s talk.

Whether you’re a clinician, a researcher, a healthcare organization, or someone who wants to bring one of our tools to the people you serve — we’d like to hear from you.

Email us Visit Hope for a Village