Biosynesi LLC

Neurological Data Mining

Advancements in deep brain stimulation: Surgical techniques and stimulation.
The goal of this project was to develop a catalog of micro-electrode recording data and neourologists’ notes and software to cross-correlate for the purpose of refining the localization of deep brain stimulation (DBS) probe placement.
Funded by the Mayfield Education and Research Foundation

Clinical Note Management

A bi-product of our database development for organizing and analyzing neurologists’ handwritten notes to correlate with microelectrode recording data is the creation of a tablet based note-taking tool. This software program provides an alternative to neurologists’ handwritten note taking during deep brain stimulation (DBS) surgery, automatically storing the data to a database and making it immediately accessible for analysis.

Motion Assessment

Developing objective methods and algorithms to assess movement using the Microsoft Kinect; ultimately leading to the replacement of UPDRS section III.
The goal of this project is to leverage existing motion detection software and adapt it for neurological assessment, electronically measuring the affects of degeneration due to movement disorders such as Parkinson’s disease and associated treatment outcomes.

Funded by the Mayfield Education and Research Foundation

Mathematical Modeling

Dissertation: Creation of a biophysical model of a striatal dorsal lateral medium spiny neuron incorporating dendritic excitation by NMDA and AMPA receptor models